杜海，农学博士，作物学博士后，教授，博士研究生导师。现任植物科学与技术系主任，专业负责人。主要从事油菜基因组学、抗逆与优质丰产研究及推广应用工作。先后主持国家自然科学基金面上项目3项、国家重点研发计划子课题1项、中国博士后基金面上资助1项、重庆市自然科学基金面上项目1项等10余个科研项目。担任国家自然科学基金、国家博士后基金、农业农村部主推技术、重庆市自然科学基金、四川省科技厅等项目通讯评审专家。担任FTPS和IJMS客邀编辑，《中国油料作物学报》编委，JAFC等20余个学术期刊同行评审专家。在Advanced Science, Horticulture Research, Plant Journal等国内外刊物发表学术论文50余篇，SCI论文被引用1400余次，高被引论文2篇。参编国家十四五规划教材《生物信息学》和《案例式分子生物学》。承担本科生《生物信息学》和《分子生物学》、研究生《现代遗传学专题》课程的教学工作。荣获四川农业大学2012-2013年度优秀博士学文论文，2018年全国高校黄大年式教师团队(成员)。
学习经历
2016-2017：Purdue University (普渡大学)，访问学者(合作导师：Jian-Kang Zhu教授)。
2013-2016：73882必赢欢迎光临网址，油菜研究中心，在职博士后(合作导师：李加纳教授)；
2005-2013：四川农业大学玉米研究所，作物遗传育种专业，硕博连读(导师：黄玉碧教授)；
2006-2010：中国农业科学院生物技术研究所，客座学生(导师：唐益雄研究员)；
2001-2005：四川农业大学农学院农学专业，农学学士。
工作经历
2023.7—至今：73882必赢欢迎光临网址，教授，博士研究生导师。
2020.7—至今：73882必赢欢迎光临网址，教授，硕士研究生导师。
2013.9-2020.6：73882必赢欢迎光临网址，副教授，硕士研究生导师。
研究方向
1. 油菜根系发育调控、养分高效、抗逆、高产基因挖掘与分子机理解析；
2. 油菜基因组与生物信息学；
3. 油菜基因组编辑、基因组育种、抗逆高产种质资源筛选与利用；
4. 油菜轻简高效、多功能利用与优质丰产增效栽培技术与推广应用。
主要科研项目
1. 国家自然科学基金面上项目：MYB转录因子BnWERs调控甘蓝型油菜根毛发育的分子机制研究(32072094)，2021-2024年(主持人)；
2. 国家自然科学基金面上项目：BnMYB93s转录因子基因调控甘蓝型油菜侧根发育的分子机制研究(31671727)，2017-2020年(主持人)；
3. 国家自然科学基金面上项目：甘蓝型油菜硫苷合成调控和转运关键基因的克隆及作用机制研究(31471528)，2015-2018年(主持人)；
4. 国家重点研发计划子课题：大田经济作物优质丰产的生理基础与调控-油菜优质丰产生理与技术调控研究(2018YFD1000900)，2018-2024年(主持人)；
5. 第55批中国博士后科学基金面上资助：调控油菜硫苷合成关键MYB基因的鉴定及其作用机制研究(2014M552297)，2014-2016年(主持人)；
6. 重庆市自然科学基金面上项目：油菜MYB转录因子BnMYBR042调控根毛发育的分子机制研究，2023-2026年(主持人)；
7. 科技部国家“973”项目：油菜高收获指数株型结构的遗传及分子解析(2015CB150201 )，2015-2020年(参研人)；
8. 重庆市横向项目(41013116)：南川方竹笋立地环境调查和品质鉴定，2016-2018年(主持人)。
发表论文(*通讯作者；#共同第一作者)
[1]. Qu C, Zhu M, Hu R, Niu Y, Chen S, Zhao H, Li C, Wang Z, Yin N, Sun F, Chen Z, Shen S, Shang G, Zhou Y, Yan X, Wei L, Liu L, Yi B, Lian J, Li J, Tang Z, Liang Y, Xu X, Wang R, Yin J, Wan H, Du H, Qian W, Chai Y, Zhou Q, He Y, Zhong S, Qiu X, Yu H, Lam HM, Lu K, Fu F, Li J. Comparative genomic analyses reveal the genetic basis of the yellow-seed trait in Brassica napus. Nat Commun. 2023, 14(1):5194. doi: 10.1038/s41467-023-40838-1. (IF2023=17.694, 一区)
[2]. Li P, Du R, Li Z, Chen Z, Li J, Du H. An integrated nitrogen utilization gene network and transcriptome analysis reveal candidate genes in response to nitrogen deficiency in Brassica napus. Front Plant Sci. 2023, 14:1187552. doi: 10.3389/fpls.2023.1187552. (IF2023=6.627, 一区)
[3]. Wang N, Deng Y, Zhang L, Wan Y, Lei T, Yang Y, Wu C, Du H, Feng P, Yin W, He G. UDP-glucose epimerase 1, moonlighting as a transcriptional activator, is essential for tapetum degradation and male fertility in rice. Mol Plant. 2023, 16(5):829-848. doi: 10.1016/j.molp.2023.03.008. (IF2023=21.949, 一区)
[4]. Cortés AJ, Du H. Molecular Genetics Enhances Plant Breeding. Int J Mol Sci. 2023, 24(12):9977. doi: 10.3390/ijms24129977. (IF2023=5.6, 二区)
[5]. Meng X, Wang Q, Hao R, Li X, Li M, Hu R, Du H, Hu Z, Yu B, Li S. RNA-binding protein MAC5A interacts with the 26S proteasome to regulate DNA damage response in Arabidopsis. Plant Physiol. 2023, 191(1):446-462. doi: 10.1093/plphys/kiac510. (IF2023=8.005, 一区)
[6]. Du H*, Hu W, Demko V and Liang Z (2022) Editorial: Evolution of crop genomes and epigenomes. Front. Plant Sci. 2022, 13:1027698. doi: 10.3389/fpls.2022.1027698 (IF2022=6.627, 二区)
[7]. Chen Z, Wu Z, Dong W, Liu S, Tian L, Li J, Du H*. MYB Transcription Factors Becoming Mainstream in Plant Roots. Int J Mol Sci. 2022, 17;23(16):9262. doi: 10.3390/ijms23169262. (IF2022=6.208, 二区)
[8]. Wei L#, Du H#, Li X, Fan Y, Qian M, Li Y, Wang H, Qu C, Qian W, Xu X, Tang Z, Zhang K, Li J, Lu K. Spatio-temporal transcriptome profiling and subgenome analysis in Brassica napus. Plant J. 2022, 111(4):1123-1138. doi: 10.1111/tpj.15881. (IF2022=7.091, 一区)
[9]. Du RJ, Wu ZX, Yu ZX, Li PF, Mu JY, Zhou J, Li JN, Du H*. Genome-Wide Characterization of High-Affinity Nitrate Transporter 2 (NRT2) Gene Family in Brassica napus. Int J Mol Sci. 2022, 23(9):4965. doi: 10.3390/ijms23094965. (IF2022=6.208, 二区)
[10]. Wu Y, Wen J, Xia Y, Zhang L, Du H*. Evolution and Functional Diversification of R2R3-MYB Transcription Factors in Plants. Horticulture Research. 2022, 9: uhac058 doi: 10.1093/hr/uhac058 (IF2022=7.291, 一区)
[11]. Chong L, Xu R, Huang P, Guo P, Zhu M, Du H, Sun X, Ku L, Zhu JK, Zhu Y. The tomato OST1-VOZ1 module regulates drought-mediated flowering. Plant Cell, 2022, koac026. doi: 10.1093/plcell/koac026. (IF2022=12.085, 一区)
[12]. Zhou J, Zhou HJ, Chen P, Zhang LL, Zhu JT, Li PF, Yang J, Ke YZ, Zhou YH, Li JN, Du H *. Genome-Wide Survey and Expression Analysis of the KT/HAK/KUP Family in Brassica napus and Its Potential Roles in the Response to K(+) Deficiency. Int J Mol Sci. 2020, 21(24):9487. doi: 10.3390/ijms21249487. (IF2021=5.924) (Citation=3)
[13]. Wen J, Li P, Ran F, Guo P, Zhu J, Yang J, Zhang L, Chen P, Li J, Du H*. Genome-wide characterization, expression analyses, and functional prediction of the NPF family in Brassica napus. BMC Genomics, 2020, 21(1):871. DOI: 10.1186/s12864-020-07274-7. (IF2020= 3.969, 二区) (Citation=3)
[14]. Li P, Wen J, Chen P, Guo P, Ke Y, Wan M, Liu M, Phan Tran LS, Li J, Du H*. MYB Superfamily in Brassica napus: Evidence for Hormone-Mediated Expression Profiles, Large Expansion, and Functions in Root Hair Development. Biomolecules, 2020, 10, 875; doi:10.3390/biom10060875. (IF2019= 3.089, 三区). (Citation=4)
[15]. Ke YZ, Wu YW, Zhou HJ, Chen P, Wang MM, Liu MM, Li PF, Yang J, Li JN, Du H*. Genome-wide survey of the bHLH super gene family in Brassica napus. BMC Plant Biol. 2020, 20(1):115. doi: 10.1186/s12870-020-2315-8. (IF2019=3.670, 二区).
[16]. Yang J, Zhou J, Zhou HJ, Wang MM, Liu MM, Ke YZ, Li PF, Li JN, Du H*. Global Survey and Expressions of the Phosphate Transporter Gene Families in Brassica napus and Their Roles in Phosphorus Response. Int J Mol Sci, 2020, 21(5). pii: E1752. doi: 10.3390/ijms21051752. (IF2020=5.924, 三区) (Citation=8)
[17]. Liang Z, Riaz A, Chachar S, Ding Y, Du H, Gu X. Epigenetic Modifications of mRNA and DNA in Plants. Mol Plant. 2020, 13(1):14-30. doi: 10.1016/j.molp.2019.12.007. (IF2019=10.812, 一区) (Citation=30, 高被引论文) .
[18]. Qiao C, Yang J, Wan Y, Xiang S, Guan M, Du H, Tang Z, Lu K, Li J, Qu C. A Genome-Wide Survey of MATE Transporters in Brassicaceae and Unveiling Their Expression Profiles under Abiotic Stress in Rapeseed. Plants (Basel). 2020, 9(9):1072. doi: 10.3390/plants9091072. (Citation=3)
[19]. Tang F, Xiao Z, Sun F, Shen S, Chen S, Chen R, Zhu M, Zhang Q, Du H, Lu K, Li J, Qu C. Genome-wide identification and comparative analysis of diacylglycerol kinase (DGK) gene family and their expression profiling in Brassica napus under abiotic stress. BMC Plant Biol. 2020, 20(1):473. doi: 10.1186/s12870-020-02691-y. (IF2020=3.497) (Citation=3)
[20]. Zhe Liang#, Yuke Geng#, Changmian Ji#, Hai Du#, Chui Eng Wong, Qian Zhang, Ye Zhang, Pingxian Zhang, Adeel Riaz, Sadaruddin Chachar, Yike Ding, Jing Wen, Yunwen Wu, Mingcheng Wang, Hongkun Zheng, Yanmin Wu, Viktor Demko, Lisha Shen, Xiao Han, Pengpeng Zhang, Xiaofeng Gu, Hao Yu. Mesostigma viride Genome and Transcriptome Provide Insights into the Origin and Evolution of Streptophyta. Adv. Sci, 2019, 7(1):1901850. doi: 10.1002/advs.201901850. (IF2019=15.804, 一区) (Citation=14).
[21]. Xiao Z, Zhang C, Tang F, Yang B, Zhang L, Liu J, Huo Q, Wang S, Li S, Wei L, Du H, Qu C, Lu K, Li J, Li N. Identification of candidate genes controlling oil content by combination of genome-wide association and transcriptome analysis in the oilseed crop Brassica napus. Biotechnol Biofuels, 2019, 12:216. doi: 10.1186/s13068-019-1557-x. (IF2019=5.452) (Citation=12).
[22]. Xiao Z, Li N, Wang S, Sun J, Zhang L, Zhang C, Yang H, Zhao H, Yang B, Wei L, Du H, Qu C, Lu K, Li J. Genome-Wide Identification and Comparative Expression Profile Analysis of the Long-Chain Acyl-CoA synthetase (LACS) Gene Family in Two Different Oil Content Cultivars of Brassica napus. Biochem Genet, 2019, 57(6):781-800. doi: 10.1007/s10528-019-09921-5. (IF2019=1.931). (Citation=5).
[23]. Liu MM, Wang MM, Yang J, Wen J, Guo PC, Ke YZ, Wu YW, Li PF, Li JN, Du H*. Evolutionary and Comparative Expression Analyses of TCP Transcription Factor Gene Family in Land Plants. Int. J. Mol. Sci, 2019, 20(14), 3591 (IF2019=4.694, 三区) (Citation=10)
[24]. Guo P, Wen J, Yang J, Ke Y, Wang M, Liu M, Ran F, Wu Y, Li P, Li J, Du H*. Genome-wide survey and expression analyses of the GRAS gene family in Brassica napus reveals their roles in root development and stress response. Planta, 2019, 250: 1051-1072 (IF2019=3.060, 二区) (Citation=5)
[25]. Wen J, Guo P, Ke Y, Liu M, Li P, Wu Y, Ran F, Wang M, Li J, Du H*. The auxin response factor gene family in allopolyploid Brassica napus. PLoS One, 2019, 14(4):e0214885. doi: 10.1371/journal.pone.0214885. (IF2019=2.766) (Citation=15).
[26]. Lu K, Wei L, Li X, Wang Y, Wu J, Liu M, Zhang C, Chen Z, Xiao Z, Jian H, Cheng F, Zhang K, Du H, Cheng X, Qu C, Qian W, Liu L, Wang R, Zou Q, Ying J, Xu X, Mei J, Liang Y, Chai YR, Tang Z, Wan H, Ni Y, He Y, Lin N, Fan Y, Sun W, Li NN, Zhou G, Zheng H, Wang X, Paterson AH, Li J. Whole-genome resequencing reveals Brassica napus origin and genetic loci involved in its improvement. Nat Commun, 2019, 10(1): 1154 (IF2018=12.353). (Citation=99).
[27]. Wang MM, Liu MM, Ran F, Guo PC, Ke YZ, Wu YW, Wen J, Li PF, Li JN, Du H*. Global Analysis of WOX Transcription Factor Gene Family in Brassica napus Reveals Their Stress- and Hormone-Responsive Patterns. Int J Mol Sci, 2018, 19(11). pii: E3470 (IF2018=3.687, 三区). (Citation=11)
[28]. Wu Y, Ke Y, Wen J, Guo P, Ran F, Wang M, Liu M, Li P, Li J, Du H*. Evolution and expression analyses of the MADS-box gene family in Brassica napus. PLoS One, 2018, 13(7):e0200762 (IF2018=2.766). (Citation=9).
[29]. 吴韵雯, 柯蕴倬, 冉凤, 文婧, 郭鹏程, 孙丽萍, 马姗姗, 李加纳, 杜海*. 甘蓝型油菜BnMYB193基因的克隆和表达分析. 农业生物技术学报, 2018, 26(7): 1155-1163.
[30]. Di F, Jian H, Wang T, Chen X, Ding Y, Du H, Lu K, Li J, Liu L. Genome-Wide Analysis of the PYL Gene Family and Identification of PYL Genes That Respond to Abiotic Stress in Brassica napus. Genes (Basel). 2018, 9(3). pii: E156 (IF2018=3.191). (Citation=26).
[31]. Zhu Y, Wang B, Tang K, Hsu CC, Xie S, Du H, Yang Y, Tao WA, Zhu JK. An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress. PLoS Genet, 2017, 13(12):e1007124 (IF2018=5.54) (Citation=24).
[32]. Du H, Ran F, Dong HL, Wen J, Li JN, Liang Z. Genome-Wide Analysis, Classification, Evolution, and Expression Analysis of the Cytochrome P450 93 Family in Land Plants. PLoS One, 2016, 11(10): e0165020 (IF2016=2.806) (Citation=16).
[33]. Mei J, Ding Y, Li Y, Tong C, Du H, Yu Y, Wan H, Xiong Q, Yu J, Liu S, Li J, Qian W. Corrigendum: Transcriptomic comparison between Brassica oleracea and rice (Oryza sativa) reveals diverse modulations on cell death in response to Sclerotinia sclerotiorum. Sci Rep, 2016, 6: 34900 (IF2016=4.259) (Citation=10).
[34]. Li W, Lu J, Lu K, Yuan J, Huang J, Du H, Li J. Cloning and Phylogenetic Analysis of Brassica napus L. Caffeic Acid O-Methyltransferase 1 Gene Family and Its Expression Pattern under Drought Stress. PLoS One. 2016, 11(11): e0165975 (IF2016=2.806) (Citation=8).
[35]. Zhang J, Zhang S, Li H, Du H, Huang H, Li Y, Hu Y, Liu H, Liu Y, Yu G, Huang Y. Identification of Transcription Factors ZmMYB111 and ZmMYB148 Involved in Phenylpropanoid Metabolism. Front Plant Sci, 2016, 7: 148. (IF2016=4.291) (Citation=12).
[36]. 杜海, 冉凤, 马珊珊, 柯蕴倬, 孙丽萍, 李加纳, 唐益雄. GmMYB042基因对类黄酮生物合成的调控作用. 作物学报, 2016, 42(1): 1-10.
[37]. 杜海, 冉凤, 刘静, 文婧，马珊珊, 柯蕴倬, 孙丽萍, 李加纳. 拟南芥硫苷生物合成相关基因的组织和胁迫诱导表达谱的全基因组分析.中国农业科学, 2016, 49(15): 2879-2897.
[38]. Du H, Liang Z, Zhao S, Nan MG, Phan Tran LS, Lu K, Huang YB, Li JN. The Evolutionary History of R2R3-MYB Proteins Across 50 Eukaryotes: New Insights Into Subfamily Classification and Expansion. Sci Rep, 2015, 5: 11037. (IF2015=5.228) (Citation=53).
[39]. Wei L, Jian H, Lu K, Filardo F, Yin N, Liu L, Qu C, Li W, Du H, Li J. Genome-wide association analysis and differential expression analysis of resistance to Sclerotinia stem rot in Brassica napus. Plant Biotechnol J, 2016, 4(6):1368-80. (IF2015=7.443) (Citation=83).
[40]. Du H, Wang YB, Xie Y, Liang Z, Jiang SJ, Zhang SS, Huang YB, Tang YX. Genome-Wide Identification and Evolutionary and Expression Analyses of MYB-related Genes in Land Plants. DNA Res. 2013, 20(5): 437-448. (IF2013=5.164) (Citation=82).
[41]. Du H, Feng BR, Yang SS, Huang YB, Tang YX. The R2R3-MYB Transcription Factor Gene Family in Maize. PLoS ONE, 2012, 7(6): e37463 (IF2012= 4.092) (Citation=138).
[42]. Du H, Yang SS, Liang Z, Feng BR, Liu L, Huang YB, Tang YX. Genome-wide analysis of the MYB transcription factor superfamily in soybean. BMC Plant Biol, 2012, 12: 106 (IF2012=3.447) (Citation=221, 高被引论文).
[43]. Du H, Huang Y, Tang Y. Genetics and Metabolic Engineering of Isoflavonoid Biosynthesis. Appl Microbiol Biotechnol, 2010, 86(5): 1293-312 (IF2010 =3.28) (Citation=92).
[44]. Du H, Zhang L, Liu L, Tang XF, Yang WJ, Wu YM, Huang YB, Tang YX. Biochemical and Molecular Characterization of the Plant MYB Transcription Factors Family. Biochemistry (Mosc), 2009, 74(1): 1-11 (IF2009=1.327) (Citation=159).
[45]. 杜海, 杨文杰, 刘蕾, 唐晓凤 吴燕民, 黄玉碧, 唐益雄. 大豆MYB转录因子基因 GmMYBJ6 和GmMYBJ7 的克隆及表达分析.作物学报, 2008, 34 (7): 1179-1187.
[46]. 杜海, 刘蕾, 唐晓凤, 高杰, 杨文杰, 吴燕民, 黄玉碧, 唐益雄. 大豆MYB 转录因子GmMYBZ2 的鉴定、突变分析及原核. 农业生物技术学报, 2009, 17(2): 301-306.
[47]. 刘蕾#, 杜海#, 唐晓凤, 吴燕民, 黄玉碧, 唐益雄. MYB 转录因子在植物抗逆胁迫中的作用及其分子机理. 遗传, 2008, 30 (10): 1265-1271.
[48]. 杨文杰, 杜海, 方芳, 杨婉身, 吴燕民, 唐益雄. 大豆两个MYB 转录因子基因的克隆及表达分析. 中国农业科学, 2008, 41(4): 961-970.
[49]. Borun Feng, Sisi Yang, Hai Du, Xianbin Hou, Junjie Zhang, Hanmei Liu and Yubi Huang. Molecular characterization and functional analysis of plant WRKY genes. African Journal of Biotechnology, 2012, 11(72), pp. 13606-13613. (Citation=9).
[50]. Gu Y, Liu Y, Zhang J, Liu H, Hu Y, Du H, Li Y, Chen J, Wei B, Huang Y. Identification and characterization of microRNAs in the developing maize endosperm. Genomics, 2013, 102 (5-6): 472-478 (IF2014=3.01) (Citation=15).
[51]. Chen J, Huang B, Li Y, Du H, Gu Y, Liu H, Zhang J, Huang Y. Synergistic influence of sucrose and abscisic acid on the genes involved in starch synthesis in maize endosperm. Carbohydr Res, 2011, 346(13): 1684-1691 (IF2011=2.332) (Citation=22).
成果与奖励
1. 国家发明专利：一种高密度油菜“油-蔬两用” 免耕直播的栽培方法 (202210513973.X)，2022；
2. 2018年全国高校黄大年式教师团队成员；
3. 获2013年四川农业大学优秀博士毕业论文；
4. 申请获得四川省农作物玉米品种审定一个(川单455)，排名第9；
5. 参编十四五规划教材《生物信息学》和《案例式分子生物学》；参与西南大学《分子生物学》本科生在线课程建设。
学术兼职
1. Frontiers in Plant Science/International Journal of Molecular Sciences客邀编辑；
2. Journal of Agricultural and Food Chemistry/BMC Plant Biology/BMC Genomic/Genomics/Frontiers in Plant Science/Frontiers in Genetics/Scientific reports/Plant Physiology and Biochemistry/Plant Science/BMC Biological Research/Plants/PloS ONE/Current Genomics/Plant Molecular Biology Reporter/PeerJ/Plant Biology/Oil Crop Science等SCI期刊的同行评审专家；
3. 国家自然科学基金通讯评审专家，农业农村部主推技术通讯评审，国家博士后基金评审专家，教育部学位与研究生教育发展中心评审专家，重庆市自然科学基金评审专家，四川省科技厅项目评审专家，《中国油料作物学报》青年编委。
研究生/博士后招生专业
1. 博士后：作物学、生物学；
2. 博士研究生：作物遗传育种、生物化学与分子生物学、生物信息学；
3. 作物遗传育种、生物化学与分子生物学、植物学、遗传学、作物栽培与耕作学。
联系方式
电话：023-68251264；E-mail: haidu81@126.com
通信地址：重庆市北碚区天生路2号73882必赢欢迎光临网址；邮编：400715